Chromosome interactions in Drosophila robusta.
نویسنده
چکیده
M O S T of the population genetics work on Drosophila species has been done with polymorphism at a single gene locus or different gene arrangements in one chromosome which behave in inheritance as single genetic units. However, little attention has been given to the problem of interactions between unlinked polymorphic loci. Consider two unlinked autosomal loci A and B and their variant alleles a and b, respectively. There will then be nine genotypes AABB, AABb, AAbb, AaBB, AaBb, Aabb, aaBB, aaBb, and aabb. If interactions between the two loci occur, then it is possible to have the relative fitnesses as shown in Table 1, which is a purely hypothetical example. While the Aabb genotype shows overdominance to AAbb and aabb genotypes, the AaBB genotype is inferior to the AABB and m B B genotypes. Thus, the study of the fitnesses of AA, Aa, and aa genotypes with the BB genotype alone will give results different from studies with the Bb or bb genotypes. Any study which does not consider the fitnesses of the nine genotypes will give results only of doubtful value. However, the knowledge of the marginal fitnesses of AA, Aa, and aa genotypes will be useful if care has been taken to randomize the background at the B locus. The single important aspect of interactions is that the fate of one locus is not independent of the others in evolution. Interactions for linked gene arrangements have been observed in several Dipterans (LEVITAN 1958a). WHITE (1957) presented evidence of interactions between pericentric inversions on two different chromosomes in Moraba scurra males. In Moraba scurra only one component of fitness, male viability, was studied. Apart from Moraba scurra, there is no organism in which any effort has been made to demonstrate the interactions between naturally occurring unlinked
منابع مشابه
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عنوان ژورنال:
- Genetics
دوره 57 2 شماره
صفحات -
تاریخ انتشار 1967